Cannatonic vs Harlequin

Harlequin and Cannatonic are two of the most famous high-CBD marijuana strains.

They are also two of the original strains that started the medical cannabis movement.

In this article, we’ll get to know them better and help you make a choice.

Cannatonic vs Harlequi

Characteristic Cannatonic Harlequin
Effects Mellow, short-lived high without anxiety, Light body high without couch-lock, Pain relief, Anti-inflammatory, Uplifting, Relaxing No intense high due to the CBD content, pain relief, Happy
Uplifting, relaxing but no couch-lock effect, anti-inflammatory
Yield Indoors: Cca 500g / m2
Outdoors: Cca 400g / plant
Indoors: Up to 700g / m2
Outdoors: Cca 600g / m2
Harvest Time Indoors: 9 – 11 weeks
Outdoors: Early October
Indoors: 8 – 9 weeks
Outdoors: Mid October
THC Content 7 – 15% 4 – 10%
CBD content 12% 10 – 15%
Height Indoors: Cca 70cm
Outdoors: short
Indoors: moderate
Outdoors: Cca 2 meters
Flavors Woody, earthy, pine, citrus, sweet Sweet, mango, herbal, pine, earthy
Genetics G13 Haze x MK Ultra 75% sativa dominant hybrid, cross of a Swiss
Sativa, Nepali Indica, Thai Sativa, and Colombian Gold
Grow difficulty Easier to grow indoors, very picky about humidity and temperature, not very resistant to mold, mildew or pests. Easier to grow indoors, picky about humidity and temperature, require stakes for support during the flowering stage



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This strain is famous for its high levels of CBD (10 to 15%) and reasonable THC (4 to 10%).

So it won’t get you very high but instead leave you with a happy and upbeat mood.

Many people looking for pain relief from many different conditions use it, as it provides a mood boost without a heavy body stone.

It also has powerful anti-inflammatory properties, making it a good choice for fibromyalgia and neuralgic pain.

Because of its light nature and mood-boosting effects, Harlequin is excellent to wake and bake.


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This is another high-CBD strain (around 12%), although this one is also higher in THC than Harlequin (7 to 15% THC).

Even with its high CBD content, most beginners will feel a decent high, and even experienced smokers will feel like they’ve taken something.

The equal CBD and THC ratio is excellent at keeping a person focused while at the same time relieving pain and inflammation.

It’s like getting the both of both worlds, a short head high with no anxiety, and a body high that relaxes and relieves pain.



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Outdoor yields can be of up to 700 grams while indoor yields are usually around 600 grams per m2.

The harvested buds are round, not too big, and with a deep green color with mild hints of purple and blue and pistils that vary from orange to vivid red.

When cured you will find the smell to be musky and with hints of tropical fruits.


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Yields for this strain are usually around 400 grams per plant outdoors and 500 grams per m2 indoors.

The buds are dense, packed, and coated in trichome crystals that will make you stare at its beautiful main cola.

Grow Difficulty


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Harlequin tends to be picky about humidity and temperature and is most suited for indoor growing.

If you want to grow it outside you need a warm climate with moderate to low humidity but given the right humidity, it can show very good resistance to mold and pests.

Flowering time for Harlequin is usually around 8 to 9 weeks but it does have a tendency to take longer, sometimes requiring up to 12 weeks for harvest.

Also, keep in mind that if you want to reach the highest level of CBD it is best to harvest your crop a little early.

Harlequin is also a clone-only strain, so if you want to grow it you will need to procure a clipping from a mature plant.

It’s important to remember that colas sometimes become so dense and large that they require stakes for support during the flowering stage.


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This is a strain that is most easily grown indoors because of its high proclivity for mold and mildew.

If despite the difficulty you decide to grow it outdoors it will be ready for harvest by early October.

The plant will benefit from humidity levels of around 60% during the vegetative stage and it should be gradually reduced to 40% in late harvest.

The indoor flowering time is between 9 and 11 weeks sometimes taking up to 12 weeks before reaching full maturity.

Plant Height


Indoors where height can be easily controlled Harlequin reaches a moderate height that fits in most grow rooms or tents.

Outdoors Harlequin can become quite tall reaching up to 2 meters.


Cannatonic is a short to medium-sized plant that doesn’t usually exceed 70 cm indoors or outdoors.



The flavor can be described as a sweet, potent herbal flavor with hints of mango and citrus along with pine notes.

Once burned the flowers have a woody, earthy smell and the flavors become more creamy and linger in the palate when smoked.


The taste shows a large number of terpenes, mostly myrcene, and linalool that you can tell from the citrusy smell.

The taste is of fresh pine and citrus that sticks on your tongue when smoked with hints of herb and pepper on the exhale.


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Harlequin is a mostly Sativa strain (75% Sativa) crossed from a Swiss Sativa, Nepali Indica, Thai Sativa, and Colombian Gold.

Although several online seed companies claim to sell seeds of Harlequin, the strain’s growers claim to have never released seeds.

Colombian Gold is an iconic cannabis strain without which many of the newer strains such as Skunk #1 wouldn’t exist.

The Thai Sativa is also famous for the “Thai Sticks” and was one of the first famous strains with a distinct citrusy smell.


Cannatonic’s first parent, the MK Ultra, is known for its extremely high CBD content, reaching up to 18%.

While G13 Haze is a relatively unknown strain that possesses high CBD concentrations as well as other characteristics to make it a good medical strain.

Cannatonic is the first commercial cannabis seed on the market with reliable 1:1 CBD and THC ratios.


As you can see, while Harlequin and Cannatonic are both excellent medical strains each has characteristics that make it ideal for different patients and growing conditions.

While Cannatonic will suit users looking for a mild high that leaves them completely functional, Harlequin will be ideal for those looking to feel the lowest possible high will still benefit from the medical effects of THC.

Cannatonic will also be easier to grow for people with reduced growing spaces or people looking for a discrete outdoor crop as it will never get exceedingly large, whereas Harlequin can get quite tall outdoors if left unchecked.

On the plus side, both are excellent medical strains that provide extreme pain relief together with relaxation and a positive mood lift.

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Hey, I’m James! The founder and head writer here at I started this site to share my passion and knowledge of all things cannabis. I used to work as a budtender in central Amsterdam, and have over 7 years of growing experience.

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